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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: RB1 All Species: 19.7
Human Site: S866 Identified Species: 36.11
UniProt: P06400 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P06400 NP_000312.2 928 106159 S866 L K R S A E G S N P P K P L K
Chimpanzee Pan troglodytes XP_509777 1075 122190 S1013 L K R S A E G S N P P K P L K
Rhesus Macaque Macaca mulatta XP_001100383 928 106126 S866 L K R S A E G S N P P K P L K
Dog Lupus familis XP_534118 897 103170 S835 L K R S A E G S N P P K P L K
Cat Felis silvestris
Mouse Mus musculus P13405 921 105320 G859 L K R S A E G G N P P K P L K
Rat Rattus norvegicus P33568 920 105007 G858 L K R S A E G G N P P K P L K
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514098 917 104520 S855 L K R S A D G S N P P N P L K
Chicken Gallus gallus Q90600 921 104417 P858 H V K R S A E P S D A P K P L
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_001071248 903 102339 G843 L K R S L D G G S A P K P L K
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_395096 1006 113492 Y937 S P A P Q L S Y C F S R S P A
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_790323 774 86478 C714 G I C K V R D C E R K F K E I
Poplar Tree Populus trichocarpa B9GLX8 1035 114624 S975 T H A Y Q S P S K D L N A I N
Maize Zea mays Q3LXA7 1010 111475 S948 T Y A F Q S P S K D L K A I N
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 86.2 99.3 90 N.A. 90.4 89.7 N.A. 81.3 73 N.A. 53.9 N.A. N.A. 23 N.A. 26.4
Protein Similarity: 100 86.3 99.5 93 N.A. 94.9 95.1 N.A. 88.2 84.1 N.A. 70.9 N.A. N.A. 42.9 N.A. 42.6
P-Site Identity: 100 100 100 100 N.A. 93.3 93.3 N.A. 86.6 0 N.A. 66.6 N.A. N.A. 0 N.A. 0
P-Site Similarity: 100 100 100 100 N.A. 93.3 93.3 N.A. 93.3 20 N.A. 80 N.A. N.A. 6.6 N.A. 0
Percent
Protein Identity: 22.1 23.2 N.A. N.A. N.A. N.A.
Protein Similarity: 40.4 42.1 N.A. N.A. N.A. N.A.
P-Site Identity: 6.6 13.3 N.A. N.A. N.A. N.A.
P-Site Similarity: 13.3 20 N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 24 0 54 8 0 0 0 8 8 0 16 0 8 % A
% Cys: 0 0 8 0 0 0 0 8 8 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 16 8 0 0 24 0 0 0 0 0 % D
% Glu: 0 0 0 0 0 47 8 0 8 0 0 0 0 8 0 % E
% Phe: 0 0 0 8 0 0 0 0 0 8 0 8 0 0 0 % F
% Gly: 8 0 0 0 0 0 62 24 0 0 0 0 0 0 0 % G
% His: 8 8 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 8 0 0 0 0 0 0 0 0 0 0 0 16 8 % I
% Lys: 0 62 8 8 0 0 0 0 16 0 8 62 16 0 62 % K
% Leu: 62 0 0 0 8 8 0 0 0 0 16 0 0 62 8 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 54 0 0 16 0 0 16 % N
% Pro: 0 8 0 8 0 0 16 8 0 54 62 8 62 16 0 % P
% Gln: 0 0 0 0 24 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 62 8 0 8 0 0 0 8 0 8 0 0 0 % R
% Ser: 8 0 0 62 8 16 8 54 16 0 8 0 8 0 0 % S
% Thr: 16 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % T
% Val: 0 8 0 0 8 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 8 0 8 0 0 0 8 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _